![]() ![]() Īccumulating evidence suggests that the RNF213 gene on chromosome 17q25.3 is an important susceptibility factor for MMD in East Asian populations. The high incidence among Asian populations, together with a familial occurrence of approximately 105 of cases, strongly suggests a genetic cause. The cause of Moyamoya disease is unknown. Although the typical phenotype affects Japanese children, North Americans affected by the disease are typically adults of Asian American, Black, or Hispanic ethnicity. Moyamoya disease is an uncommon, progressively occlusive intracranial arteriopathy of the anterior cerebral circulation, typically presenting as an acute infarct with a high risk for subsequent strokes. ![]()
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